The NSF Directorate of Biological Sciences (BIO), the Established Program to Stimulate Competitive Research (EPSCoR), and the Directorate for Technology, Innovation, and Partnerships (TIP) have jointly funded a workshop that aims to build new connections among key BioSci communities to successfully conduct ‘Use-inspired Research’. The workshop will consist of a series of events: two free virtual Pre-Workshop MicroLabs and an In-Person Workshop (for 120 selected participants representing diverse groups and organizations). Participants of the workshop will co-create the structures and processes that guide how diverse organizations support and value use-inspired science and will guide NSF to create use-inspired tracks within the Directorate for Biological Sciences and the Office of Integrative Activities. Our vision for this workshop is to support researchers across career stages who want to take advantage of new funding and partnership opportunities within and associated with the new Technology, Innovation, and Partnership Directorate at NSF and to support government and private organizations who want their science needs to be more broadly understood and incorporated into research priorities.